TABLE 3.
Influence of the pharmacokinetic parameters of aripiprazole and dehydro‐aripiprazole on pupillometric parameters
| Aripiprazole | Dehydro‐aripiprazole | |||
|---|---|---|---|---|
| Single dose | Single dose | Multiple dose | ||
| Variable | AUClast (ng·h/mL) | Tmax (h) | AUC24h (ng·h/mL) | Cmax (ng/mL) |
| MAX | ‐‐‐ | ‐‐‐ | P = .042 ↓↓ | P = .029 ↓↓ |
| MIN | ‐‐‐ | ‐‐‐ | P = .050 ↓↓ | P = .049 ↓↓ |
| CON | P = .029 ↓↑ | P = .043 ↓↓ | P = .047 ↓↓ | P = .015 ↓↓ |
| ACV | ‐‐‐ | ‐‐‐ | P = .049 ↓↓ | P = .041 ↓↓ |
| MCV | P = .004 ↓↑ | ‐‐‐ | P = .046 ↓↑ | P = .027 ↓↑ |
| ADV | P = .034 ↓↓ | ‐‐‐ | ‐‐‐ | P = .033 ↓↓ |
| T75 | ‐‐‐ | ‐‐‐ | ‐‐‐ | P = .045 ↓↓ |
The arrows show the relationship between pharmacokinetic and pupillometric parameters. The first arrow refers to the pharmacokinetic parameter, while the second arrow refers to the pupillometric parameter. ↓↑ is indirectly proportional, while ↓↓ is directly proportional with the changes.
Abbreviations: MAX: maximum pupil diameter; MIN: minimum pupil diameter; CON: percent of constriction; LAT: latency; ACV: average constriction velocity; MCV: maximum constriction velocity; ADV: average dilation velocity; T75: total time taken by the pupil to recover 75% of the initial resting pupil size. Cmax: maximum plasma concentration; Tmax: time to reach the maximum plasma concentration; AUC24h: 24 h area under the concentration–time curve; AUClast: area under the curve from time zero to the last observed time point.