TABLE 1.
Patient characteristics (median (range)) and dosing information of the population, up to the last available sample. For time‐changing characteristics the median of the individual median is presented. Ibuprofen doses are calculated based on absolute dose administered and (interpolated) current weight. Loading and maintenance doses were based on a 3‐day regimen and identified by number of dose
| Appropriate for gestational age | Small for gestational age | Total population | |
|---|---|---|---|
| Patient characteristics | |||
| Preterm infants (n) | 60 | 7 | 67 |
| Sex (male/female) | 32/28 | 3/4 | 35/32 |
| Gestational age (wk) | 26.1 (24.0–30.1) | 26.7 (24.6–28.9) | 26.1 (24.0–30.1) |
| Birth weight (kg) | 0.91 (0.59–1.45) | 0.67 (0.47–0.95) | 0.87 (0.47–1.45) |
| Current weight (kg) | 0.85 (0.53–1.59) | 0.74 (0.45–1.04) | 0.83 (0.45–1.59) |
| Part of twin (n) | 30 | 3 | 33 |
| Postnatal age at treatment initiation (d) | 3 (1–8) | 4 (2–12) | 3 (1–12) |
| Bilirubin (μmol/L) [number of patients] | 97.4 (42.5–177.3) [37] | 75.5 (47.7–104.3) [6] | 94.9 (42.5–177.3) [43] |
| Albumin (g/L) [number of patients] | 28.9 (25.0–36.5) [14] | 26.6 [1] | 28.7 (25.0–36.5) [15] |
| Coadministration of fluconazole (n) | 17 | 2 | 19 |
| Ibuprofen dosing | |||
| Duration of ibuprofen treatment (d) | 3 (0–15) | 2 (1–4) | 3 (0–15) |
| Infusion duration (min) | 15 (3–30) | 15 (0–30) | 15 (0–30) |
| Entire treatment period | |||
| Dose of ibuprofen (mg/kg) | 9.6 (4.6–22.7) | 8.1 (4.5–20.4) | 9.5 (4.5–22.7) |
| First treatment cycle | |||
| Loading dose of ibuprofen (mg/kg) | 11 (5–23) | 10 (7–20) | 11 (5–23) |
| Maintenance dose of ibuprofen (mg/kg) | 6 (5–15) | 5 (4–9) | 6 (4–15) |
| Second treatment cycle | |||
| Loading dose of ibuprofen (mg/kg), n | 18 (5–20) [17] | 19 (7–20) [3] | 18 (5–20) [20] |
| Maintenance dose of ibuprofen (mg/kg), n | 9 (5–19) [11] | 9 (5–19) [11] | |
| Third treatment cycle | |||
| Loading dose of ibuprofen (mg/kg), n | 14 (8–20) [4] | 14 (8–20) [4] | |
| Maintenance dose of ibuprofen (mg/kg), n | 9 (9–10) [3] | 9 (9–10) [3] | |
| Samples | |||
| Time after last dose (h) | 15.9 (0–112.4) | 15.3 (0.5–22.1) | 15.8 (0–112.4) |
| Observed concentrations S‐ibuprofen (mg/L) | 20.61 (0.08–84.17) | 9.22 (0.91–31.78) | 20.02 (0.08–84.17) |
| Observed concentrations R‐ibuprofen (mg/L) |
0 (0–24.73) |
0 (0–9.45) | 0 (0–24.73) |