Table 3. Nested Models Between Reproductive Life Span, Age at Menarche, Age at Menopause, and Risk of Nonfatal Cardiovascular Disease Events.
| Characteristic | Hazard ratio (95% CI) | |||||
|---|---|---|---|---|---|---|
| Model 1a | Model 2a | Model 3a | Model 4b | Model 5c | Model 6d | |
| –log Likelihood | 87 117 | 87 317 | 87 102 | 87 078 | 87 092 | 87 086 |
| Reproductive life span, y | ||||||
| <30 | 1.69 (1.57-1.83) | NA | NA | 1.70 (1.57-1.84) | 1.25 (1.08-1.45) | NA |
| 30-32 | 1.31 (1.21-1.42) | NA | NA | 1.31 (1.21-1.42) | 1.09 (0.98-1.20) | NA |
| 33-35 | 1.16 (1.09-1.24) | NA | NA | 1.16 (1.09-1.24) | 1.04 (0.96-1.12) | NA |
| 36-38 | 1 [Reference] | NA | NA | 1 [Reference] | 1 [Reference] | NA |
| 39-41 | 0.90 (0.84-0.96) | NA | NA | 0.86 (0.81-0.92) | 1.01 (0.94-1.09) | NA |
| 42-44 | 0.76 (0.70-0.83) | NA | NA | 0.71 (0.66-0.78) | 0.95 (0.84-1.07) | NA |
| ≥45 | 0.58 (0.50-0.67) | NA | NA | 0.52 (0.45-0.60) | 0.75 (0.61-0.91) | NA |
| Age at menarche, y | ||||||
| ≤10 | NA | 1.13 (1.00-1.27) | NA | 1.34 (1.19-1.52) | NA | 1.12 (1.00-1.27) |
| 11 | NA | 1.16 (1.07-1.24) | NA | 1.27 (1.18-1.37) | NA | 1.14 (1.06-1.23) |
| 12 | NA | 0.98 (0.91-1.05) | NA | 1.03 (0.96-1.10) | NA | 0.98 (0.91-1.05) |
| 13 | NA | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] |
| 14 | NA | 1.00 (0.93-1.06) | NA | 0.95 (0.89-1.01) | NA | 1.00 (0.94-1.07) |
| 15 | NA | 1.07 (0.99-1.15) | NA | 0.97 (0.89-1.04) | NA | 1.07 (0.99-1.16) |
| ≥16 | NA | 1.17 (1.07-1.28) | NA | 0.98 (0.90-1.08) | NA | 1.16 (1.07-1.27) |
| Age at menopause, y | ||||||
| <40 | NA | NA | 1.92 (1.69-2.18) | NA | 1.54 (1.27-1.87) | 1.90 (1.67-2.15) |
| 40-44 | NA | NA | 1.55 (1.44-1.68) | NA | 1.33 (1.16-1.52) | 1.55 (1.43-1.68) |
| 45-49 | NA | NA | 1.22 (1.15-1.29) | NA | 1.18 (1.09-1.27) | 1.22 (1.14-1.29) |
| 50-51 | NA | NA | 1 [Reference] | NA | 1 [Reference] | 1 [Reference] |
| 52-53 | NA | NA | 0.92 (0.85-0.98) | NA | 0.92 (0.85-0.99) | 0.92 (0.86-0.98) |
| 54-55 | NA | NA | 0.78 (0.72-0.85) | NA | 0.81 (0.73-0.90) | 0.78 (0.72-0.85) |
| ≥56 | NA | NA | 0.68 (0.62-0.75) | NA | 0.79 (0.68-0.92) | 0.68 (0.62-0.75) |
Abbreviation: NA, not applicable.
a
Models 1 to 3 were adjusted for women’s year at birth, race/ethnicity, education, smoking status at baseline, baseline body mass index, number of children, age at first birth, and menopausal hormone therapy use.
b
Model 4 included both reproductive life span and age at menarche in addition to the covariates.
c
Model 5 included both reproductive life span and age at menopause in addition to the covariates.
d
Model 6 included both age at menarche and age at menopause in addition to the covariates.