Table 4.

Results from DAVID’s function enrichment analysis of significant genes between the control and TBPH_HIGH groups at the 5% FDR cutoff. The gene functional enrichment analysis revealed that the two genes P450 1A1 and 1B1 affected several enriched functional categories including aromatase activity, microsome, and iron ion binding.

Category	Term	PValue	Genes	List Total	Pop Hits	Pop Total	Fold Enrichment	Bonferroni
GOTERM_MF	GO:0070330~aromatase activity	0.001549	LOC105930482, LOC105926177	2	4	2582	645.5	0.0046
INTERPRO	IPR008066:Cytochrome P450, E-class, group I, CYP1	0.002167	LOC105930482, LOC105926177	4	3	4152	692.0	0.0193
UP_KEYWORDS	Microsome	0.003108	LOC105930482, LOC105926177	3	5	3216	428.8	0.0397
INTERPRO	IPR002401:Cytochrome P450, E-class, group I	0.009366	LOC105930482, LOC105926177	4	13	4152	159.7	0.0812
INTERPRO	IPR017972:Cytochrome P450, conserved site	0.010802	LOC105930482, LOC105926177	4	15	4152	138.4	0.0931
GOTERM_MF	GO:0005506~iron ion binding	0.011232	LOC105930482, LOC105926177	2	29	2582	89.0	0.0333
INTERPRO	IPR001128:Cytochrome P450	0.011519	LOC105930482, LOC105926177	4	16	4152	129.8	0.0990
GOTERM_MF	GO:0020037~heme binding	0.011619	LOC105930482, LOC105926177	2	30	2582	86.1	0.0345
UP_KEYWORDS	Monooxygenase	0.014255	LOC105930482, LOC105926177	3	23	3216	93.2	0.1703
UP_KEYWORDS	Heme	0.015489	LOC105930482, LOC105926177	3	25	3216	85.8	0.1837
UP_KEYWORDS	Endoplasmic reticulum	0.015489	LOC105930482, LOC105926177	3	25	3216	85.8	0.1837
GOTERM_CC	GO:0005789~endoplasmic reticulum membrane	0.023406	LOC105930482, LOC105926177	3	27	2294	56.6	0.0686
UP_KEYWORDS	Iron	0.025339	LOC105930482, LOC105926177	3	41	3216	52.3	0.2837
UP_KEYWORDS	Oxidoreductase	0.04914	LOC105930482, LOC105926177	3	80	3216	26.8	0.4806