TABLE 1.
Body weights and toxicity scores presented by soman-challenged Macaca fascicularis subjected to different pretreatments and posttreated with atropine, 2-PAM, and midazolam
Doses (i.m.): 15.08 µg/kg soman; 0.4 mg/kg atropine sulfate; 30 mg/kg 2-PAM chloride; and 0.32 mg/kg midazolam. Clinical signs that characterize each toxicity score are described in the text of the Materials and Methods section. In short, a score of 0 was assigned to subjects presenting normal behavior. Scores of 1 to 2, 3, and 4 to 5 were assigned to subjects presenting mild, moderate, and severe signs of toxicity, respectively, as described in the text. Subjects were humanely euthanized (euth) as soon as they developed life-threatening signs of toxicity (toxicity score 5).
| Subject ID | Body weight (kg) | Time of FOB observations after soman challenge | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 min | 30 min | 1 h | 2 h | 3 h | 4 h | 6 h | 8 h | 24 h | ||
| Oral pretreatment: saline | ||||||||||
| 12-092 | 4.38 | 4 | 4 | 4 | 4 | 4 | 5 (euth) | |||
| 24-098 | 4.63 | 4 | 4 | 4 | 5 (euth) | |||||
| 20-106 | 4.13 | 4 | 4 | 5 (euth) | ||||||
| 21-104 | 4.75 | 4 | 4 | 4 | 4 | 5 (euth) | ||||
| Oral pretreatment: 1.2 mg/kg pyridostigmine bromide | ||||||||||
| 23-099 | 6.15 | 4 | 4 | 4 | 4 | 3 | 3 | 3 | 3 | 2 |
| 15-102 | 5.71 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 5 (euth) | |
| 16-103 | 4.03 | 4 | 4 | 4 | 4 | 4 | 4 | 5 (euth) | ||
| 02-109 | 3.60 | 4 | 4 | 4 | 4 | 3 | 2 | 2 | 2 | 0 |
| 03-110 | 3.77 | 4 | 4 | 4 | 4 | 5 (euth) | ||||
| Oral pretreatment: 1.5 mg/kg galantamine HBr | ||||||||||
| 22-105 | 4.72 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 05-112 | 3.89 | 3 | 3 | 3 | 2 | 2 | 1 | 1 | 1 | 0 |
| 09-107 | 4.47 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13-101 | 7.40 | 3 | 3 | 3 | 2 | 1 | 0 | 0 | 0 | 0 |
| 06-113 | 6.09 | 3 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| Oral pretreatment: 3.0 mg/kg galantamine HBr | ||||||||||
| 08-095 | 5.34 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| 07-097 | 4.44 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| 17-100 | 4.45 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 11-093 | 4.52 | 4 | 4 | 4 | 3 | 4 | 4 | 4 | 3 | 3 |
| 10-108 | 5.10 | 3 | 3 | 4 | 4 | 4 | 3 | 3 | 3 | 2 |
| 01-096 | 4.34 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 3 |