FIG 8.

(A to C) Changes in the frequency of the SIV-specific CD8⁺ T cells after the administration of the anti-CCR4-DT (A), low-dose IL-2-DT (B), and high-dose IL-2-DT (C). SIV-specific CD8⁺ T cells were assessed based on the expression of IFN-γ, IL-2, MIP-1β, TNF-α, and CD107a. Both the individual expression of the specificities and their combinations were assessed, as illustrated in the legend. Polyspecificities are illustrated as circles around the SIV-specific responses. The mean of the sum of total expression with the standard error of the mean (SEM) is presented within each pie.