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SP-2509 treatment does not affect nuclear entry or genome interactions during early infection. MRC-5 cells were infected at an MOI of 10 PFU/cell with EdC-labeled KOS in the presence or absence of SP-2509. At 2.5 hpi, cells were fixed and viral genomes were covalently attached to a fluorophore (vDNA) and probed with antibodies specific for ICP4, ICP8, or Pol II. Scale bars, 5 μm. Green and red trace of merge (RG) panel is shown at right.
