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. 2020 Sep 16;10:15156. doi: 10.1038/s41598-020-72028-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Goldmann kinetic perimetry in patients with biallelic FAM161A mutations. (a) Examples of visual fields from 6 patients at different ages show that constriction of the fields occurs relatively early in the majority of FAM161A patients, although occasionally fields may be better preserved into the fourth or even fifth decade. Target I4e shown in red, target III4e in green and target V4e in blue. (b) Visual field area (using target V4e) plotted versus age in patients with FAM161A mutations as compared to other causative genes in our cohort. Visual field areas from 50 FAM161A patients and 39 patients with other RP-causing genes (DHDDS [blue], MAK [red] and RPGR [green]- males only) are presented. Each symbol represents the average between the two eyes. Only genes with data from at least 10 patients were included.