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. 2020 Sep 16;10:15156. doi: 10.1038/s41598-020-72028-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cone flicker ERG amplitudes at 1st testing. A total of 231 genetically identified patients were included, and the average cone flicker amplitude between the two eyes as measured at the earliest ERG test performed in each of the patients is presented. Genes with at least 20 patients each (FAM161A [red, with different shapes representing the three genotypes)], DHDDS [orange diamond], EYS [green diamond], RPGR [blue diamond]) are specifically marked, while genes with less than 20 patients per gene share the same annotation (gray x) on the graph (ABCA4- only patients with an RP phenotype, ADAM9, BBS2, C2ORF71, C8ORF37, CDHR1, CERKL, CNGA1, CNGB1, CRB1, IMPG2, MAK, NRL, PDE6A, PDE6B, PLA2G5, PRPF3, RDH12, RHO, RP1, RP2, RPGRIP1, USH1C, and USH2A). Since in many patients cone flicker responses were non-detectable, to allow better visualization these "zero" points were spread over the values of – 10–0 uV. Lower limit of normal for cone flicker ERG amplitudes at our lab is 60 uV, marked by a horizontal dashed line at the top of the figure.