Table 3.

Phenotypic characteristics of individuals with PNES and deleterious genetic variants.

ID	Sex	Identified variant (ACMG-AMP classification)	Age	Age at PNES onset	Cognition/neuro exam	MRI	Febrile seizures	Medical comorbidities	Psychiatric comorbidities	FH of seizures	FH of psychiatric disease
PNES1	Male	Pathogenic	33	33	Normal/normal	Normal	No	Migraine, chronic pain	Mood disorder	No	No
PNES2	Male	Pathogenic	59	55	Normal/normal	Normal	No	HTN, DM, HPL, COPD, OSA, CAD/CHF, CKD	None	No	No
PNES3	Female	Pathogenic	33	30	Normal/normal	Unknown	No	None	Anxiety, PTSD	No	Yes—PTSD, anxiety
PNES4	Male	Likely pathogenic	58	12	Normal/normal	Normal	No	HTN, OSA	Mood disorder	No	No
PNES5	Female	Pathogenic	50	50	Normal/normal	Normal	No	Hypothyroidism	Mood disorder, anxiety	Yes—aunt	Yes—mood disorder
PNES6	Female	Likely pathogenic	45	40	Normal/normal	Normal	No	HTN, HPL, CAD, CVD	Mood disorder, anxiety, PTSD	No	No
PNES7	Female	Uncertain significance	39	34	Normal/normal	Normal	No	Migraine, HTN, DM, OSA, PCOS, optic neuritis	Mood disorder, anxiety	No	Yes—mood disorder, OCD
PNES8	Female	Uncertain significance	50	50	Normal/normal	Normal	No	Migraine, HPL	Anxiety	No	No
PNES9	Female	Uncertain significance	48	28	Normal/normal	Mild chronic microvascular disease	No	DM, OSA, IBS, CVD	Mood disorder, anxiety	No	No
PNES10	Female	Uncertain significance	43	7	Normal/normal	Mild chronic microvascular disease	No	Migraine, DM, CKD, OSA, hypothyroidism	Mood disorder, anxiety	Yes—MGM	No
PNES11	Female	Uncertain significance	26	15	Normal/normal	Normal	No	Migraine, chronic pain	Mood disorder, anxiety, PTSD	Yes—MGF	Yes—mood disorder, anxiety
PNES12	Male	Uncertain significance	53	51	Normal/normal	Normal	No	None	Mood disorder	Yes—mother	No

HTN: hypertension, DM: diabetes mellitus, HPL: hyperlipidemia, COPD: chronic obstructive pulmonary disease, CAD: coronary artery disease, CHF: congestive heart failure, CKD: chronic kidney disease, OSA: obstructive sleep apnea, PTSD: post-traumatic stress disorder, Mood Disorder: depression or bipolar disorder, CVD: cerebrovascular disease, PGF: paternal grandfather, PCOS: polycystic ovarian syndrome, OCD: obsessive–compulsive disorder, MGF: maternal grandfather, MGM: maternal grandmother, IBS: irritable bowel syndrome.