Fig. 1. Wound-activated gene signature found at baseline of oral mucosa is activated in DFUs.

a Representative image of a diabetic foot ulcer (DFU). b Heatmap of genes regulated in DFUs. c Volcano plot indicating differentially regulated genes in DFUs. Dotted line region is magnified on the right panel highlighting some of the most significantly upregulated genes in DFUs. d Wound-activated gene signature of a subset of genes involved in epidermal differentiation, intermediate filaments and inflammatory cytokines shows similarities between baseline oral mucosa and DFUs.