Figure 1.

Experimental concept of “cassette” binding of dodecaborate to an antibody receptor target on a cancer cell. The Z33 peptide is conjugated to dodecaborate (Z33-DB) and binds to the Fc of the objective antibody. The antibody can recognize and bind to target receptors on the cancer membrane. Next, EGFR activation by EGF induces macropinocytosis, leading to efficient cellular uptake of the Z33-DB compound. After Z33-DB cellular uptake, thermal neutron radiation induces effective cancer cell-killing activity through BNCT.