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. 2020 Sep 3;11:576367. doi: 10.3389/fpsyt.2020.576367

Figure 2.

Figure 2

|Transplantation of bone marrow HSC reverses maternal diabetes-induced gene suppression in PBMC in autistic offspring. The 6-week-old male offspring from either the control (CTL) or maternal diabetes (STZ) group received transplantation of bone marrow HSC from either the control (CTL-HSC) or maternal diabetes (STZ-HSC) group, and mice were used for further biomedical analysis 5 weeks after transplantation. (A) The HSC were isolated for ChIP analysis, n = 4. (B) The mRNA levels in HSC, n = 4. (C) The PBMC were isolated for ChIP analysis, n = 4. (D) The mRNA levels in PBMC, n = 4. (E) The representative pictures of western blotting. (F) The quantitated protein levels in PBMC for (E), n = 5. (G) SOD2 activity assay, n = 5. *P < 0.05, vs. CTL/CTL-HSC group. Data were expressed as mean ± SEM.