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. 2020 Sep 3;11:576367. doi: 10.3389/fpsyt.2020.576367

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Copyright © 2020 Lu, Xiao, Guo, Liang, Wang, Xu, Liu, Wang, Zeng, Liu, Li and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transplantation of bone marrow HSC reverses maternal diabetes-induced oxidative stress in PBMC in autistic offspring. The 6-week-old male offspring from either the control (CTL) or maternal diabetes (STZ) groups received transplantation of bone marrow HSC from either the control (CTL-HSC) or maternal diabetes (STZ-HSC) group, and the mice were used for further biomedical analysis 5 weeks after transplantation. (A) ROS formation in PBMC, n = 5. (B) Quantitation of 3-nitrotyrosine formation, n = 5. (C) 8-OHdG formation, n = 5. (D) Quantitation of γH2AX formation. (E) Representative γH2AX western blotting band for (D), n = 5. (F) Quantitation of 8-oxo-dG formation, n = 5. (G) Representative pictures of 8-oxo-dG staining for oxidative stress (green) and DAPI staining for nuclei (blue) in PBMC, n = 4. *P < 0.05, vs. CTL/CTL-HSC group. Data were expressed as mean ± SEM.