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. 2020 Sep 3;11:576367. doi: 10.3389/fpsyt.2020.576367

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Copyright © 2020 Lu, Xiao, Guo, Liang, Wang, Xu, Liu, Wang, Zeng, Liu, Li and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transplantation of bone marrow HSC reverses maternal diabetes-induced inflammatory cytokine release from PBMC in autistic offspring. The 6-week-old male offspring from either the control (CTL) or maternal diabetes (STZ) group received transplants of bone marrow HSC from either the control (CTL-HSC) or maternal diabetes (STZ-HSC) group, and the PBMC were isolated for further analysis. (A) mRNA levels by qPCR, n = 4. (B) IL-1β secretion, n = 5. (C) IL-6 secretion, n = 5. (D) MCP1 secretion, n = 5. *P < 0.05, vs. CTL/CTL-HSC group; ¶P < 0.05, vs. STZ/CTL-HSC group. Data were expressed as mean ± SEM.