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. 2020 Sep 16;11:4643. doi: 10.1038/s41467-020-18412-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Heatmap of gene ontology transporter annotated genes enriched in either extended feeding (EXF) or time-restricted feeding (TRF), grayed out cells indicate non-significant rhythmicity, and color z-score normalized expression (a). Serum metabolite significant differences in acrophase, amplitude, or MESOR (b). Heatmap of serum metabolites with differential acrophase between EXF and TRF; cell color indicates z-score normalized expression, and Metabolon super-pathway annotation is indicated in color to the right. (c). Scatterplot of serum metabolites with significant differences in amplitude, with amplitude of EXF on the x-axis, and TRF on the y-axis (top panel), and serum metabolites with differential MESOR, with EXF on the x-axis, and TRF on the y-axis (bottom panel), colors indicate super-pathway annotation (d). Expression of genes with significant differences in FDR adjusted p value in either amplitude (#) or acrophase (+) derived from CircaCompare. Points are individual datapoints, and line represents cosinor regression fit. Black line indicates EXF, and red line indicates TRF. Triangles on the horizontal axis indicate feeding time, line type indicates FDR adjusted RAIN derived p value (e); ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. n = 11 participants.