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. 2020 Sep 16;10:15195. doi: 10.1038/s41598-020-72290-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Cell cycle analysis in glioma cells treated with either 10 μM PT2385 or vehicle in normoxic and hypoxic conditions for 72 h demonstrate no measurable difference between treatment groups. (B) Fluorescent microscopy of cell viability testing in renal cell carcinoma and glioma cells treated with either PT2385 or vehicle in hypoxic conditions with viable cells appearing green and dead cells appearing red demonstrate no visual difference between treatment groups, (C) Real-time PCR gene expression fold changes for hypoxia pathway HIF2α downstream genes were decreased after PT2385 treatment in the BTCOE 4536 cell line and unchanged in the BTCOE 4795 cell line.