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. 2020 Sep 16;10:15195. doi: 10.1038/s41598-020-72290-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Experimental design for chemoradiation (50 mg/kg PO qD TMZ during radiation followed by 5 days on/23 days off cycles) combined with PT2385 (10 mg/kg PO BID PT2385 in 21 days on/7 days off cycles) studies (using model BTCOE 4795). (B) Kaplan Meier survival curve demonstrating no significant difference in survival in animals treated with RT/TMZ/PT2385 versus RT/TMZ/Placebo (p = 0.44). (C) Representative bioluminescent images of a cage receiving placebo treatment and a cage receiving PT2385 treatment after 14 weeks with more animals alive and smaller tumor burdens amongst PT2385 treated animals. (D) Graph of bioluminescent values during 14 weeks of consecutive imaging demonstrate no significant difference between RT/TMZ/Placebo animals compared to RT/TMZ/PT2385 (t 1.13, p = 0.32).