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. 2020 Sep 16;10:15212. doi: 10.1038/s41598-020-72241-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of denoised CARS endoscopy images. The images are for (a) an input observed with an imaging rate of 12.5 images/min (a short exposure time of 4.8 s), denoised with (b) the BM3D filter and (c) N2N with ensemble, and (d) ground truth observed with an imaging rate of 0.4 images/min (a long exposure time of 160 s). Nerves lie at the center of the images with lipid rich tissue on each side. The CARS images in the second column are images cropped from the white rectangles in the left images. The line profiles of the cropped images are shown in (e). Scale bar indicates $50 μ m$ . The polarization direction of two laser beams is horizontal in images.