Table 3.

Mutations detected in plasma ctDNA only of discordant sample pairs.

Patient no.	Cancer type	Tumor stage	Position	Gene	Mutation (amino acid change)	Mutation type	% Mutation: tumor (reads)	% Mutation: plasma (reads)	% Mutation: WBC (reads)
48	UKN	IV	chr7:55241708	EGFR	p.G719A	SNP	0.0 (3528)	3.4 (22307)	0.0 (190)
			chr7:55242511	EGFR	p.D761Y	SNP	0.0 (1000)	3.5 (21853)	0.0 (310)
			chr12:25398285	KRAS	p.G12C	SNP	0.0 (2529)	4.8 (17379)	0.0 (312)
			chr12:25398281	KRAS	p.G13D	SNP	0.0 (2536)	3.6 (17465)	0.0 (313)
75	AC	IIIA	chr7:55249071	EGFR	p.T790M	SNP	0.0 (2845)	2.8 (9887)	0.0 (1106)
			chr12:25398284	KRAS	p.G12V	SNP	0.0 (19015)	1.1 (14689)	0.0 (7065)
78	AC	IIIA	chr7:55249071	EGFR	p.T790M	SNP	0.0 (130)	21.5 (10975)	0.0 (244)
90	AC	IIIA	chr17:7577538	TP53	Intronic	SNP	0.0 (7432)	9.5 (86317)	0.0 (7353)
114	SCC	IIIA	chr7:140453136	BRAF	p.V600E	SNP	0.0 (7669)	43.1 (17175)	0.0 (3180)
			chr7:55241708	EGFR	p.G719A	SNP	0.0 (10692)	59.6 (91440)	0.0 (4044)
			chr7:55242464	EGFR	p.745_749del	DEL	0.0 (11397)	60.4 (77443)	0.0 (4330)
			chr7:55242511	EGFR	p.D761Y	SNP	0.0 (11386)	61.6 (76946)	0.0 (4321)
			chr7:55249005	EGFR	p.S768I	SNP	0.0 (4691)	4.3 (10185)	0.0 (2257)
			chr7:55249012	EGFR	p.D770delinsDG	INS	0.1 (4688)	3.9 (9952)	0.1 (2257)
			chr12:25398285	KRAS	p.G12C	SNP	0.0 (14166)	66.6 (58977)	0.0 (5117)
			chr12:25398281	KRAS	p.G13D	SNP	0.0 (14211)	65.0 (59150)	0.0 (5138)
			chr3:178936091	PIK3CA	p.E545K	SNP	0.0 (13901)	51.4 (42929)	0.0 (5936)
118	AC	IV	chr7:55242511	EGFR	p.D761N	SNP	0.0 (10264)	1.1 (9481)	0.0 (8745)
			chr3:178936091	PIK3CA	p.E545K	SNP	0.0 (8801)	1.2 (19609)	0.0 (5406)
123	AC	IIIA	chr7:55241708	EGFR	p.G719D	SNP	0.0 (9315)	1.1 (26694)	0.0 (13761)
			chr7:55242511	EGFR	p.D761N	SNP	0.0 (13069)	1.0 (21772)	0.0 (19806)
			chr12:25398281	KRAS	p.G13V	SNP	0.0 (16150)	1.0 (17697)	0.0 (17816)
139	AC	IIIB	chr7:55249063	EGFR	p.Q787Q	SNP	0.3 (5833)	4.1 (5984)	0.0 (4334)

SCC: squamous cell carcinoma; AC: adenocarcinoma; UKN: unknown; SNP: single nucleotide polymorphism; DEL: deletion; INS: insert.