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. 2020 Sep 1;5(36):23237–23246. doi: 10.1021/acsomega.0c02991

Figure 1.

Figure 1

Expression profiles of circRNAs in GC. (a) Circos plot showing the density distribution of circRNAs on chromosomes. (b) Cluster heat map displaying the most up and downregulated circRNAs. Each column indicates a sample, while each row indicates an individual circRNA. The red and blue colors represent high and low expression, respectively. All samples from T3N1M0 had the same expression pattern, as well as those from T3N3M0. (c) Volcano plot showing the differences in circRNA expression levels between T3N3M0 and T3N1M0 GC tumor tissues. The red and green dots represent significantly up and downregulated circRNAs, respectively. One hundred 16 circRNAs were significantly upregulated and 91 were significantly downregulated. (d) KEGG pathway enrichment analysis of circRNA-encoding genes. Well-known pathways, including the Ras signaling pathway, adherens junction, and FoxO signaling pathway, were enriched.