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. 2020 Sep 1;5(36):23237–23246. doi: 10.1021/acsomega.0c02991

Figure 7.

Figure 7

Relative migration and invasion of SNU-216 cells with stable overexpression of circRIMS. (a) Relative expression of miR-148 and miR-218 in each GC cell line with stable circRIMS overexpression or knockdown. The residual hsa-miR-148a-5p and hsa-miR-218-5p levels in the cells with high circRIMS expression were less than those observed in the control cells, and vice versa. (b) Wound closure analysis after creating a scratch through a layer of confluent cells for microRNA rescue experiments. The hsa-miR-148a-5p and hsa-miR-218-5p mimics remarkably inhibited wound closure. (c) Migration ability through a filter toward serum-containing medium in a Boyden chamber assay for microRNA rescue experiments. The hsa-miR-148a-5p and hsa-miR-218-5p mimics were transfected into the SNU-216-pLCDH-circRIMS stable cell line to rescue the effect caused by the high expression of circRIMS successfully.