Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Molecular dynamics simulation of KRAS mutated at position 34 show increased dynamics in SW1. (a) In KRASWT, Pro34 interacts with the Mg2+ ion secondarily through hydrogen bonding with a solvent molecule. The distance indicated by the red dashed line is plotted in b. Blue dash lines show nearby polar contacts involving solvent. (b) Distances between side chains of residues 34 and water 1,003 are plotted over time of the simulation
