Table 1.

Principal natural echinocandins, representative strains that produce them, acyl side-chains, amino acids (AA) in positions 1–6 of peptide core and accession numbers for genomes or gene clusters.

Naturally occurring echinocandins	Representative strain	Class, family classification	Acyl side-chain	AA1	AA2	AA3	AA4	AA5	AA6	Genome or gene cluster accession
Acrophiarin (antibiotic S31794/	Penicillium arenicola	Eurotiomycetes, Aspergillaceae	Myristic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S,4S-dihydroxy-L-homoTyr	3R-hydroxy-L-GIn	3S-hydoxy-4S-methyl-L-Pro	MN518690
Echinocandin B	Aspergillus pachycristatus NRRL 11440 (ATCC 58397)	Eurotiomycetes, Aspergillaceae	Linoleic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S,4S-dihydroxy-L-homoTyr	L-Thr	3S-hydoxy-4S-methyl-L-Pro	JX421684
Mulundocandin	Aspergillus mulundensis DSMZ5745	Eurotiomycetes, Aspergillaceae	12-Methylmyristic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S,4S-dihydroxy-L-homoTyr	L-Ser	3S-hydoxy-4S-methyl-L-Pro	KP742486, PVWQ00000000
Aculeacin A	Aspergillus aculeatus ATCC 16872 (NRRL 5094)	Eurotiomycetes, Aspergillaceae	Palmitic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S,4S-dihydroxy-L-homoTyr	L-Thr	3S-hydoxy-4S-methyl-L-Pro	JGI ATCC16872 v1.1
Pneumocandin A0	Glarea lozoyensis ATCC 20868	Leotiomycetes, Helotiaceae	10,12-Dimethylmyristic	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S,4S-dihydroxy-L-homoTyr	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	ALVE00000000
Sporiofungin	Pezicula radicicola NRRL 12192	Leotiomycetes, Dermateaceae	10,12-dimethyl myristic acid	4R,5R-dihydroxy-L-Orn	L-Ser	4R-hydroxy-L-Pro	3S-hydroxy-L-homoTyr	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	PDUO00000000
FR901379 (WF11899A)	Coleophoma cylindrospora FERM BP 6252	Leotiomycetes, Dermateaceae	Palmitic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S, 7-dihydroxyl-L-homoTyr-7-O-sulfate	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	AB723722, AB720725, PDLN00000000
FR209602	Coleophoma crateriformis FERM BP 5796	Leotiomycetes, Dermateaceae	Palmitic acid	4R,5R-dihydroxy-L-Orn	L-Ser	4R-hydroxy-L-Pro	3S,4S,7-trihydroxyl-L-homoTyr-7-O-sulfate	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	AB720076, PDLN00000000
FR190293	Venustampulla echinocandica FERM BP 5553	Leotiomycetes, Pleuroascaceae	10,12-dimethyl myristic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S, 7-dihydroxyl-L-homoTyr-7-O-sulfate	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	AB720726, NPIC00000000
FR227673a	Chalara sp.	Leotiomycetes, family unknown	12,14-dimethylpalmitic acid	4R,5R-dihydroxy-L-Orn	L-Thr	4R-hydroxy-L-Pro	3S, 7-dihydroxyl-L-homoTyr-7-O-sulfate	3R-hydroxy-L-Gln	3S-hydoxy-4S-methyl-L-Pro	None available

^a.Not studied. Included here for comparative purposes. See reference.