Table 3.

Sequence comparisons between proteins in the pneumocandin, echinocandin B and acrophiarin gene clusters.

Pneumocandin biosynthetic proteins	Predicted function	Acrophiarin biosynthetic proteins	Coverage %; Identity %	Echinocandin B biosynthetic proteins	Coverage %; Identity %
GLNRPS4	Non-ribosomal peptide synthetase	PANRPS4	98; 65	EcdA	98; 55
GLPKS4	Polyketide synthase	Absent	No	Absent	No
GLligase	AMP-dependent ligase	PALigase	100; 59	EcdI	98; 57
GLTRT	ABC transporter	PATRT	99; 60	EcdL	99; 51
GLHYD	Thioesterase	PAHYD	100; 57	Absent	no
GLP450–1	Cytochrome P450	PAP450–1	98; 57	HtyF	93; 52
GLP450–2	Cytochrome P450	PAP450–2	99; 55	EcdH	98; 49
GLOXY-1	Oxygenase	PAOXY-1	99; 67	EcdG	99; 56
GLOXY-2	Oxygenase	PAOXY-2	100; 69	HtyE	100; 64
GLOXY-3	Oxygenase	PAOXY-3	93; 66	Absent	No
GLOXY-4	Oxygenase	PAOXY-4	100; 71	EcdK	100; 62
GLHtyA	2-Isopropylmalate synthase	PAHtyA	82; 67	HtyA	93; 64
GLHtyB	d-Amino acid aminotransferase	PAHtyB	98; 74	HtyB	100; 64
GLHtyC	Isopropylmalate dehydrogenase	PAHtyC	98; 73	HtyC	99; 71
GLHtyD	3-Isopropylmalate dehydratase	PAHtyD	100; 65	HtyD	95; 62
GLHYP	Hypothetical protein	PAHYP	99; 38	EcdJ	56; 51

See Cacho and colleagues (2012) and Li and colleagues (2015) for gene nomenclature.