TABLE 2.
Clinical Outcomes | Total (n = 129) | Control Group (n = 59) | Lopinavir/Ritonavir Group (n = 51) | Chloroquine Group (n = 19) | Control vs Lopinavir/Ritonavir | Control vs Chloroquine | ||
P1 | OR1 (95% CI) | P2 | OR2 (95% CI) | |||||
Fever duration, median (range), d | 8 (5–10), n = 89 | 8 (6–11), n = 44 | 7.5 (4.8–9.3), n = 38 | 6 (4–9), n = 7 | 0.146 | 0.910 (0.802 to 1.033) | 0.690 | 0.958 (0.778 to 1.181) |
Time from illness onset to, median (range), d | ||||||||
Chest CT improvement | 15 (13–19.3), n = 114 | 15.5 (11–20.8), n = 52 | 13 (15–19), n = 47 | 14 (12–20), n = 15 | 0.949 | 1.003 (0.92 to 1.084) | 0.770 | 0.984 (0.886 to 1.093) |
Negative nucleic acid conversion | 23 (15–33.8), n = 119 | 21 (15–28.8), n = 59 | 23 (17–35.5), n = 45 | 16 (14–41), n = 15 | 0.285 | 1.018 (0.985 to 1.051) | 0.839 | 1.004 (0.963–1.047) |
Severe cases, n (%) | 6 (4.7) | 2 (3.4) | 3 (5.9) | 1 (5.3) | 0.882 | 1.163 (0.158 to 8.568) | 0.714 | 1.583 (0.136 to 18.5) |
Changes of Ct value from day 1 to day 7, median (range) | ||||||||
N gene | 9.0 (3.9–13.3), n = 44 | 5 (2–11), n = 19 | 7 (5.0–12.5), n = 13 | 8.0 (6.6–20.8), n = 12 | 0.228 | 0.918 (0.800 to 1.055) | 0.055 | 0.895 (0.798 to 1.002) |
ORF1ab gene | 8.9 (3.0–13.4), n = 44 | 4 (2–8), n = 19 | 8.5 (5.4–13.5), n = 13 | 7.6 (4.5–21), n = 12 | 0.172 | 0.916 (0.808 to 1.039) | 0.077 | 0.920 (0.838 to 1.009) |