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Ropivacaine inhibits the expression of IL-1β and IL-18. HUVECs were stimulated with high glucose (25 mM) with or without ropivacaine (0.25, 0.5%) or MCC950 (5 μM) for 24 h. (A) Secretion of IL-1β and (B) secretion of IL-18 [*, P < 0.01 vs normal glucose; #, P < 0.01 high glucose only; $, P < 0.01 vs high glucose + ropivacaine (0.25%), N = 5–6].
