Table 2. Analytical Performance of the Published Methods for CN and ATCA.

technique	analyte	matrix	LLOD (ng/mL)	LLOQ (ng/mL)	range (ng/mL)	R2	runtime (min)	sample size (μL)	refs
HS-GC/NPDa	CN	blood	11	50	50–5000	0.975–0.999	10	500	(27)
HS-GC/MSb	CN	blood	20	70	0–50 000	0.999	19.1	250	(28)
GC/MSc	CN	blood	130	N/A	260–26 000	0.999	23	200	(29)
GC/MS	CN	plasma	26	260	260–420 000	0.999	18.1	100	(30)
LCMS/MSd	CN	blood	10	26	25–26 000	0.992	6	25	(31)
LC/MS/MS	ATCA	blood	0.43	1.5	30–900	0.999	16	100	(15)
GC/MS	ATCA	blood	24	34	30–1000	0.992	13	100	(32)
GC/MS	ATCA	urine	25	50	10–2000	N/A	11	100	(8)

^aHeadspace gas chromatography with a nitrogen–phosphorus detector.

^bHeadspace gas chromatography–mass spectrometry.

^cGas chromatography–mass spectrometry.

^dLiquid chromatography–tandem mass spectrometry.