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. 2020 May 29;59(32):13511–13515. doi: 10.1002/anie.202003958

Figure 2.

Figure 2

Identification of sulfonium intermediates in malleicyprol biosynthesis. A) Volcano plot analysis comparing pellet extracts of B. thailandensis variants Pbur and PburΔburA. B) Volcano plot analysis comparing supernatant extracts of B. thailandensis variants Pbur and PburΔburI (Figure S2). C) Proposed DMSP biosynthesis in B. thailandensis. D) Production of two bis‐malleicyprol (2 a, m/z 611.3589) diastereomers in gene inactivation mutants of B. thailandensis Pbur monitored by UHPLC‐MS (EIC in negative ion mode). E) Genomic alignment of the DMSP assembly line from S. mobaraensis to the bur biosynthetic gene cluster.