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CYP51 azole inhibition profiles. Inhibition profiles for 5d (•), 5f (•), 12c (•) and fluconazole (•) were determined in CYP51 reconstitution assays containing 1 μM CaCYP51 or 0.25 μM Δ60HsCYP51 with lanosterol as substrate. IC50 determinations were performed in duplicate with mean values shown along with standard deviations. Relative velocities of 1.00 correspond to an actual velocity of 0.911±0.141 min−1 for CaCYP51 and 8.16±2.84 min−1 for Δ60HsCYP51.
