Table 4.

Binding affinity (K _d) and IC₅₀ values for compounds against CaCYP51.

Cmpd				CaCYP51	K d
	R1	R2	X	IC50 [μM]a	[nM]
5 b	4‐F	H	CH	1.41	87±27
5 c	4‐Cl	H	CH	1.01	60±4
5 d	4‐Cl	Cl	CH	0.39	17±5
5 e	2,4‐diCl	H	CH	0.99	83±26
5 f	2,4‐diCl	Cl	CH	0.46	62±17
5 g	4‐CH3	H	CH	2.45	144±47
5 h	4‐CF3	H	CH	2.21	85±19
5 i	4‐OCH3	H	CH	0.91	55±10
5 j	3,4‐diOCH3	H	CH	6.15	–
5 k	4‐Cl	H	N	4.32	167±17
7	–	–	–	1.96	–
12 a	H	–	–	0.54	115±16
12 b	4‐F	–	–	0.20	55±27
12 c	4‐Cl	–	–	0.33	43±18
12 d	4‐OCH3	–	–	0.79	110±22
Fluc				0.31	41±13

[a] Curve‐fitted IC₅₀ values (v _i=z _o+{v _o/1+([I]/IC₅₀)ⁿ Mean K _d values of three replicates are shown along with associated standard deviations.