Table 6.
Sterol composition (% of total sterols) of untreated and treated wild‐type C. albicans strains.
|
|
|
Sterol composition [%] |
|
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
Untreated (DMSO only) |
Fluconazole 0.06 [μg/mL] |
5 d 0.06 [μg/mL] |
5 f 0.015 [μg/mL] |
12 c 0.5 [μg/mL] |
|||||
|
|
CA14 |
SC5314 |
CA14 |
SC5314 |
CA14 |
SC5314 |
CA14 |
SC5314 |
CA14 |
SC5314 |
|
ergosterol |
76.9±3.8 |
77.2±3.8 |
63.8±3.4 |
72.8±3.3 |
7.8±6.5 |
2.7±2.3 |
4.3±0.5 |
9.1±5.5 |
3.5±1.3 |
24.9±5.5 |
|
diol[a] |
|
|
0.2±0.4 |
|
8.2±6.0 |
17.6±7.1 |
7.5±4.6 |
11.7±1.4 |
9.2±1.2 |
7.2±5.2 |
|
lanosterol |
3.8±0.6 |
5.2±5.0 |
19.6±1.5 |
14.5±1.7 |
40.4±2.2 |
41.0±5.5 |
43.6±1.8 |
38.6±3.6 |
43.6±1.5 |
34.5±2.9 |
|
eburicol |
|
0.4±0.3 |
8.5±1.0 |
4.0±0.4 |
26.4±5.0 |
20.5±4.4 |
26.1±0.1 |
21.0±3.3 |
22.4±1.1 |
14.0±3.5 |
|
total 14α‐methylated sterols |
3.8 |
5.6 |
31.4 |
22.2 |
90.0 |
95.8 |
77.2 |
89.3 |
93.3 |
70.6 |
[a] 14α‐Methyl ergosta‐8,24(28)‐dien‐3,6‐diol.