Table 2.
Resistance rates[a] of S. aureus clinical isolates.
|
|
ADEP2 |
ADEP4 |
ADEP7 |
ADEP9 |
||||
|---|---|---|---|---|---|---|---|---|
|
ADEP exposure[b] |
4× MIC |
10× MIC |
4× MIC |
10× MIC |
4× MIC |
10× MIC |
4× MIC |
10× MIC |
|
S. aureus ATCC 29213 |
7×10−7 |
7×10−7 |
9×10−7 |
9×10−7 |
6×10−7 |
n.d. |
5×10−7 |
6×10−7 |
|
S. aureus 133 |
3×10−6 |
n.d. |
2×10−6 |
n.d. |
4×10−6 |
n.d. |
4×10−6 |
n.d. |
[a] Resistance rates were determined by plating bacteria on agar containing ADEP‐concentrations that prevented the growth of wild‐type cells (i.e., the fourfold or tenfold excess of the minimal growth inhibitory concentration). The number of resistant colonies was determined. For comparison, a resistance rate of 10−6 (i.e., one out of a million plated cells grows to a colony) is deemed high, 10−8 moderate and <10−9 rather low. [b] ADEP level applied in Mueller‐Hinton agar for selection of spontaneous resistance mutants.