Table 3.

ClpP mutations detected in resistant clones (RC) generated by ADEP selection pressure.

[a] Listed numbers are mapped to start methionine in position 1 for all species. [b] In cases, where the nature of the defect is obvious (e.g., premature stop) or where the mutation occurred in a region of known, or here confirmed, specific function (e.g., active site, ADEP binding site, oligomerisation sensor, N‐terminal gate, ring‐ring interaction, intra‐ring interaction), this information is provided here. Locations of mutations in less well characterised areas are depicted in brackets (e.g., ClpP core – i.e., globular head domain, equatorial interface and C terminus). Resistant clones (RC) are listed below the wild type from which they are derived. Mutants characterised in detail in this study are underlined. [c] For a depiction of the ADEP binding site see Figure S1.