Skip to main content
. Author manuscript; available in PMC: 2020 Sep 17.
Published in final edited form as: Mol Cancer Ther. 2016 Jun 20;15(9):2251–2258. doi: 10.1158/1535-7163.MCT-15-0908

Table 5.

Lapatinib steady-state plasma trough concentrations (ng/mL) in gastric cancer subjects with and without prior partial gastrectomy

Parameter Intact stomach Resected stomach Ratioa
Cmin (ng/mL) at Week 1 821 (633–1,064; n = 57) 532 (279–1,017; n = 9) 0.65 (0.36–1.16; P = 0.219)
Cmin (ng/mL) at Week 6 1,027 (712–1,482; n = 40) 175 (68–452; n = 6) 0.17 (0.07–9.40; P = 0.001)

Abbreviations: Cmin, minimum plasma concentration.

a

Ratio, comparing steady-state plasma trough concentrations (ng/mL) between patients with gastric cancer with and without prior partial gastrectomy; geometric means, 90% CI.