Table 3.
Decrease from baseline in mean inflammatory lesion count
| Week | Minocycline 3%, mean ± SD | Minocycline 1%, mean ± SD | Vehicle, mean ± SD | Minocycline 3%, LSM (95% CI) | Minocycline 1%, LSM (95% CI) | Vehicle, LSM (95% CI) |
|---|---|---|---|---|---|---|
| 1 | 6·6 ± 8·2 | 5·6 ± 8·3 | 5·1 ± 7·5 | 6·6 (8·2–5·0) | 5·7 (7·4, 4·1) | 5·0 (6·8–3·2) |
| 4 | 10·5 ± 9·5 | 8·4 ± 8·8 | 6·9 ± 7·1 | 10·5 (12·2–8·7) | 8·5 (10·2–6·7) | 7·0 (8·9–5·1) |
| 6 | 12·3 ± 9·12 | 9·7 ± 10·0 | 7·8 ± 8·6 | 12·3 (14·1–10·5) | 9·7 (11·6–7·9) | 7·8 (9·8–5·9) |
| 9 | 14·1 ± 10·1 | 11·5 ± 10·8 | 7·2 ± 10·3 | 14·0 (15·9–12·0) | 11·5 (13·5–9·5) | 7·3 (9·5–5·2) |
| 12 | 13·1 ± 13·6 | 12·6 ± 12·4 | 8·9 ± 10·8 | 12·9 (15·3–10·6) | 12·5 (14·9–10·1) | 8·1 (10·7–5·5) |
| 16 | 12·8 ± 12·1 | 11·3 ± 12·6 | 8·0 ± 11·6 | 12·6 (15·0–10·3) | 11·3 (13·6–8·9) | 8·3 (10·8–5·7) |
LSM, least squares mean; CI, confidence interval.