Table 1.
Average IC50 values [confidence interval (CI) 95 %; n>3] at 23 °C for the inhibition of bovine erythrocyte GPx activity by mercaptosuccinic acid (MSA) and pentathiepins 1–8, and average GI50 values (CI 95 %; n>4) at 37 °C for growth inhibition of the SISO human cervix cancer cell line.
|
Cmpd |
Enzyme inhibition IC50/ |
Inhibition of cell viability GI50/ |
|---|---|---|
|
|
[μM] (CI 95 %) |
[μM] (Cl 95 %) |
|
MSA |
5.86 (4.21–8.14) |
57.1 (47.6–68.3) |
|
1 |
1.76 (1.39–2.24) |
n.d. |
|
2 |
0.52 (0.45–0.61) |
n.d. |
|
3 |
0.47 (0.38–0.59) |
n.d. |
|
4 |
2.44 (2.17–2.75) |
8.9 (5.9–13.3) |
|
5 |
1.86 (1.67–2.04) |
n.d. |
|
6 |
0.95 (0.90–0.99) |
3.5 (2.6–4.7) |
|
7 |
0.40 (0.23–0.69) |
1.5 (1.3–1.8) |
|
8 |
0.83 (0.62–1.13) |
1.4 (1.3–1.5) |
n.d.: not determined due to poor aqueous solubility