Figure 1.

PMI analysis of potential fragments. A: Conformers of pyrrolidine scaffold 1 (top) and exemplar fragments (bottom). B: Conformers of piperidine scaffold 2 (top) and exemplar fragments (bottom). Compounds with conformations within the grey areas were selected for synthesis. C: Conformers of 33 selected fragments (top) and global minimum energy and selected higher energy 3D conformers of 1 l and 2 j. Red dots indicate global minimum energy conformers and blue dots indicate higher energy conformers.