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Structural changes in the airways of allergic asthma patients: Epithelial barrier dysfunction and airway remodelling. Asthmatic airway epithelium exposed to allergens (A) results in the disruption of adherens junctions (Aj) and tight junctions (Tj), which is accompanied by loss of ciliated cells, mucus hypersecretion (M), thickening of the basal membrane (B), subepithelial fibrosis (F), increased smooth muscle mass (S) and excessive deposition of ECM (E)
