Figure 6.

The effect of mesenchymal stromal cell‐derived exosomes (Exo) and/or lipopolysaccharide (LPS) on dendritic cell (DC)‐induced lymphocyte proliferation. Immature DCs (Ctrl), Exo (100 μg/ml)‐treated DCs, LPS (0.1 μg/ml)‐treated DCs, and Exo + LPS‐treated DCs were treated with mitomycin‐C. Cells were then cocultured with carboxyfluorescein succinimidyl ester (CFSE)‐labeled splenic lymphocytes at ratios of 1:3 (a), 1:10 (b), and 1:30 (c) for 72 hr. Data represent the mean fluorescence intensity (MFI; arbitrary units [AU] of fluorescence) ± SEM triplicate value of CFSE intensity. *p < .05, **p < .01, and ***p < .001. SEM, standard error of the mean