Table 2.
Summary statistics for high vs low donor‐derived cell‐free DNA (dd‐cfDNA)
| Measurement | Statistics | All patients | Low (dd‐cfDNA < 0.5%) | High (dd‐cfDNA ≥ 0.5%) | P value |
|---|---|---|---|---|---|
| dd‐cfDNA measurements a (%) | N | 79 | 37 | 42 | ‐ |
| Mean (SD) | 1.05 (1.267) | 0.25 (0.087) | 1.76 (1.40) | ||
| Median (Q1, Q3) | 0.64 (0.21, 1.40) | 0.21 (0.19, 0.29) | 1.40 (0.87, 2.02) | ||
| Min, Max | 0.19, 6.70 | 0.19, 0.49 | 0.52, 6.70 | ||
| Change in estimated glomerular filtration rate (eGFR; 3‐6 mo) | N | 79 | 37 | 42 | .019 b |
| Mean (SD) | −2.85 (7.526) | −0.74 (7.369) | −4.74 (7.247) | ||
| Median (Q1, Q3) | −2.00 (−5.00, 1.00) | 0.00 (−3.00, 2.00) | −3.50 (−8.00, −1.00) | ||
| Min, Max | −29.00, 16.00 | −29.00, 12.00 | −20.00, 16.00 | ||
| % Change in eGFR (3‐6 mo) | N | 79 | 37 | 42 | .004 b |
| Mean (SD) | −4.70 (16.937) | −0.40 (18.149) | −8.54 (14.98) | ||
| Median (Q1, Q3) | −3.89 (−9.89, 2.33) | 0.00 (−4.92, 4.76) | −8.50 (−16.22, −1.39) | ||
| Min, Max | −70.73, 33.33 | −70.73, 33.33 | −37.50, 32.65 | ||
| Presence of donor‐specific antibodies (3‐6 mo) | Percentage | 18/79 (22.9%) | 1/37 (2.7%) | 17/42 (40.5%) | <.001 c |
| Recurrent rejection | Percentage | 9/79 (11.4%) | 0/37 (0.0%) | 9/42 (21.4%) | .003 c |
a
0.19 is the numerical value used for dd‐cfDNA measurements denoted by <0.19.
b
Kolmogorov‐Smirnov two‐sample test (high vs low).
c
Fisher's exact test (high vs low).