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. 2020 Apr 7;46(5):478–492. doi: 10.1111/nan.12610

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© 2020 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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New diagnoses after methylation profiling: (A) Overview of initial (left) and new diagnoses after MP (right) in cases classified as ‘Establishing new better diagnosis (≥0.9)’ (n = 49). (B) WHO grade effects in cases with establishment of new diagnosis: Difference between WHO grade original diagnosis and final diagnosis for cases categorized as ‘Establishment of new better diagnosis (≥0.9)’ (n = 49), subdivided by reasons to perform MP. Green shades: downgraded, blue shades: unchanged, red shades: upgraded.