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. 2020 Jul 2;62(3):351–357. doi: 10.1002/mus.26995

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© 2020 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Nusinersen and onasemnogene abeparvovec therapies do not increase SMN protein levels in whole blood early in life. Case series for patients treated with onasemnogene abeparvovec (A), onasemnogene abeparvovec plus nusinersen (B), or only nusinersen (C). Blue arrows indicate the start of onasemnogene abeparvovec therapy, while red arrows indicate the start of nusinersen treatment. SMN, survival motor neuron; SMN2, survival motor neuron 2 gene [Color figure can be viewed at wileyonlinelibrary.com]