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. 2020 Jul 21;26(47):10871–10881. doi: 10.1002/chem.202001795

Figure 2.

Figure 2

Synthesis and binding affinity of F‐PSMA‐MIC01. (A) Synthesis route of the alkyne‐Glu‐urea‐Lys motif and the reference compound F‐PSMA‐MIC01. (B) Radiolabeling towards radiotracer [18F]‐PSMA‐MIC01. a) Manual synthesis route of [18F]PSMA‐MIC01. The final radiotracer was obtained in an overall radiochemical yield of 9 % in a total production time of 148 min, including purification of intermediate and product. b) The automated synthesis route using the FlowSafe radiosynthesis module. (C–D) logIC50 determination of the F‐PSMA‐MIC01 (C) and the precursor of [68Ga]PSMA‐11 (D) using the cell‐based competitive binding radioassay with [68Ga]PSMA‐11 as competitor on the PSMA‐positive LNCaP cell line. Mean values ± SD (n=3).