Figure 1.

Treatment initiation patterns taking into account the patient's basal factor VIII coagulant activity (FVIII:C) levels for (A) surgical procedures (B) bleeding episodes: (A1) within major and minor procedures; (A2) within the different basal FVIII:C level categories for surgical procedures; (B1) within major and minor bleeding episodes; (B2) within the different basal FVIII:C categories for bleeding episodes. For (A2) and (B2), the number of surgical procedures or bleeding episodes is reported above each bar.

‡Modality to correct FVIII:C level was missing for one patient

* One procedure was performed under long‐term prophylaxis

**Eight procedures were performed either under long‐term prophylaxis (5) or within 3 days following VWF administration for other reason (2), or without factor VIII co‐administration in one patient with type 1 VWD