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. 2020 Feb 25;9(6):756–767. doi: 10.1002/cpdd.780

Figure 1.

Figure 1

Structural representation of model with parallel Michaelis‐Menten and linear elimination of dupilumab. F, bioavailability; IV, intravenous; kcp, central‐to‐peripheral rate; kpc, peripheral‐to‐central rate; ka, absorption rate; ke, elimination rate; Km, Michaelis–Menten constant; SC, subcutaneous; Vc, central volume of distribution; Vm, maximum target‐mediated rate of elimination; Vp, peripheral volume.