Figure 1.

Mitochondrial pathways implicated in Autism Spectrum Disorder (ASD) etiology. Differentially methylated genes in our dataset interact in multiple enriched canonical pathways (Table 1). When examining the enriched pathways in our ASD dataset, we find metabolic pathways which converge on the TCA cycle which could decrease ATP production via the electron transport chain, ETC, and the accumulation of reactive oxygen species, ROS. The differentially methylated genes have a putative association with mitochondrial dysfunction in ASD. Differentially methylated genes are coded in color corresponding to their respective canonical pathways which are indicated in color‐coded boxes. In these pathways, only relevant starting, intermediate and end‐molecules are shown, where arrows can depict multiple reaction steps. Genes shown in color are differentially methylated in our dataset.