Table 1.
All patients n = 135 | Randomised patients after ASCT | |||
---|---|---|---|---|
No further treatment n = 30 | Bortezomib maintenance n = 30 | |||
Age (median; range) | 57 (34–66) | 54 (36–65) | 56 (34–66) | |
Male sex | 78% | 77% | 80% | |
WHO performance | ||||
WHO 0 | 105 (78%) | 25 (83%) | 25 (83%) | |
WHO 1 | 60 (19%) | 5 (17%) | 4 (13%) | |
WHO 2 | 5 (4%) | 1 (3%) | ||
Ann Arbor stage | ||||
II | 11 (8%) | 1 (3%) | 3 (10%) | |
III | 8 (6%) | 2 (7%) | 2 (7%) | |
IV | 116 (86%) | 27 (90%) | 25 (83%) | |
MIPI score | ||||
Low | 77 (57%) | 21 (70%) | 15 (50%) | |
Intermediate | 43 (32%) | 6 (20%) | 11 (37%) | |
High | 13 (10%) | 3 (10%) | 3 (10%) | |
Unknown | 2 (1%) | 1 (3%) | ||
Bone marrow involvement | 112 (83%) | 26 (87%) | 24 (80%) | |
MIB1 | <30% | 62 (46%) | 11 (37%) | 17 (57%) |
≥30% | 25 (18%) | 8 (26%) | 5 (17%) | |
unknown | 48 (36%) | 11 (37%) | 8 (26%) | |
P53 | <50% | 68 (50%) | 17 (57%) | 18 (60%) |
≥50% | 7 (5%) | 1 (3%) | 0 (0%) | |
unknown | 60 (45%) | 12 (40%) | 12 (40%) |