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. 2020 Mar 23;72(2):656–670. doi: 10.1002/hep.31052

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© 2019 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Cholesterol lipoprotein profile in LHM is humanized and depends on the human donor’s hepatocytes. Cholesterol lipoprotein profiles were assessed by size‐exclusion chromatography. (A) Cholesterol profile of the human donor A (n = 1), of the LHM engrafted with his primary hepatocytes (LHM‐A, n = 4), and of LMM (n = 7). Cholesterol profiles of LHM transplanted with F1 (n = 11) (B), F2 (n = 12) (C), M1 (n = 8) (D), or M2 (n = 5) (E) hepatocytes. The profiles represent the mean chromatograms, and the shaded area around them represents the SEM. See Supporting Fig. S1 for the cholesterol profiles of human donor B and LHM‐B, Supporting Fig. S2 for the correlation between liver repopulation and cholesterol phenotype, and Supporting Table S1 for genetic data of human donors.