TABLE 2.
Demographics and clinical characteristics of the GTCS hypoxemia subgroups
| Characteristics | Hypox mild/moderate (n = 11) |
Hypox severe (n = 11) |
p‐value |
|---|---|---|---|
| Age, y (mean ± SD) | 38.1 ± 12.1 | 35.4 ± 14.7 | 0.50 |
| sex (M:F) | 5:6 | 4:7 | 0.47 |
| disease duration (y, mean ± SD) | 19.9 ± 11.2 | 15.9 ± 10.6 | 0.25 |
| GTCS/y (mean ± sd) | 23.8 ± 28.6 | 11.4 ± 19.2 | 0.42 |
| Number of AEds (mean ± sd) | 2.75 ± 1.1 | 3.0 ± 0.8 | 0.67 |
| TBV, mL3 (mean ± SD) | 1106 ± 109.6 | 1140.7 ± 101.6 | 0.28 |
| hypox duration (s, mean ± sd) | 169.5 ± 117.2 | 81.9 ± 38.4 | 0.31 |
| Extent hypox (%, mean ± sd) | 13.3 ± 6.1 | 41.9 ± 15 | <0.001* |
| GTCS duration (s, mean ± sd) | 44.7 ± 17.3 | 47.9 ± 18.0 | 0.68 |
| Seizure onset/type (count) | |||
| Focal > bilateral t‐c | 9 | 9 | NA |
| Generalized onset | 2 | 2 | NA |
| data from two SUDEP cases | Hypoxemia duration (s) | Hypoxemia extent (%) | |
| Case one | 385 | 10 | |
| Case two | 95 | 55 |
Abbreviations: AEDs, anti‐epileptic drugs; GTCS, generalized tonic‐clonic seizure; Hypox, hypoxemia; ml, milliliters; s, seconds; TBV, total brain volume; T‐C, tonic‐clonic.